37 lines
2.1 KiB
Markdown
37 lines
2.1 KiB
Markdown
---
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contributors: []
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date: '2025-05-07'
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external_url: https://doi.org/10.23668/psycharchives.16330
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layout: publication
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params:
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licenses: []
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projects: []
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title: Neural, behavioral, and speech indicators of mood-congruent bias in major depressive
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disorder
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topics:
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- dfg-206-09
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---
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Aim: This study aims to explore the neural, behavioral, and speech indicators of mood-
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congruent bias in Major Depressive Disorder (MDD), investigating the relationship between
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emotional processing biases and cognitive control deficits in MDD.
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Method: Using a novel video paradigm during fMRI, facial expressions (happy/sad) were
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subliminally presented (16.7 ms) congruent or incongruent with video content (happy/sad) in a
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large sample (N = 126; MDD: n = 60, Control: n = 66). Psychological testing and speech
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recordings during a storytelling task of positive and negative life events were conducted outside
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the scanner.
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Results: During dynamic emotional cues, faster and more accurate detection was apparent when
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the emotion of the video content and the subliminal prime expression were congruent. Patients
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exhibited reduced task performance (subjective ratings and reaction times) compared to
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controls. Reduced accuracy was found in MDD particularly when happy videos were
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interrupted by a sad primer. Neuroimaging showed increased activation in the right inferior and
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middle occipital and temporal gyri. An interaction between speech features and psychological
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measures was not moderated by the group.
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Conclusion: Neuroimaging reflects compensatory mechanisms in MDD, indicating increased
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cognitive effort in processing emotional content. Multimodal evidence highlights the
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coexistence and mutual contribution of emotional and cognitive mechanisms, which together
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underscore maladaptive patterns that may exacerbate mood-congruent biases and the
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persistence and intensity of depressive symptoms.
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Schräder, J., Sieberg, R., Menne, F., Dörr, F., Tröger, J., Habel, U., König, A., & Wagels, L. (2025). <i>Neural, Behavioral, and Speech Indicators of Mood-Congruent Bias in Major Depressive Disorder</i>. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.16330
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